1 Ingredients

Each vial of Biobrains contains:

• Active ingredient: Choline 600 mg
• Excipients: q.s. 7 ml

Dosage form: Oral solution

2 Effects and Indications of Biobrains

2.1 Effects of Biobrains

 

Choline is an essential nutrient for liver, muscle, and brain functions, as well as lipid metabolism, cell membrane composition, and repair.

Choline alfoscerate (CA, L-alpha-glycerylphosphorylcholine), a semi-synthetic derivative of phosphatidylcholine, is a common precursor of acetylcholine in the brain. CA has been reported to improve memory and cognition in patients with Alzheimer’s disease (AD) and stroke. Moreover, its neuroprotective effect has been reported in experimental models of AD, stroke, and pilocarpine-induced seizures. For these neurodegenerative conditions, using a cholinergic precursor nutraceutical may be a therapeutic option. Some clinical studies have demonstrated benefits of Choline alfoscerate in patients with cognitive impairment.

2.2 Indications of Biobrains

Condition	Specific Use
Stroke	Acute episode Post-stroke recovery
Traumatic Brain Injury	Acute episode Post-trauma recovery Post-neurosurgery recovery
Dementia	Memory decline Cognitive impairment Apathy/disorientation Dizziness, vertigo, headache  Reduced movement, concentration
Alzheimer's Disease	Elderly patients with symptoms such as hearing/vision loss, headache, dizziness, poor circulation leading to cognitive decline
Neurological Disorders	Depression, anxiety Brain injury complications Stroke complications Arterial obstruction (intermittent claudication syndrome)
Vascular brain disease	Cognitive decline
Vestibular dizziness	Nausea, vomiting Vertigo

3 Dosage and Administration of Biobrains

3.1 Dosage

1 vial, 2–3 times per day, continuously for 4–6 weeks

3.2 Administration

Taken orally.

4 Contraindications

Do not use Biobrains in patients with:

• Asthma

• Urinary or digestive stones

• Active gastric or duodenal ulcer

• Psychiatric disorders

• Hypersensitivity to choline

• Pregnancy

• Extrapyramidal syndrome

• Heart failure

• Lactation

• Second- or third-degree atrioventricular block

• Cardiac arrhythmias

5 Side effects

System	Symptoms
Skin	Rash, itching, acne Hives, erythema
Digestive	Diarrhea  Gastrointestinal disorders Nausea, vomiting
Nervous System	Psychomotor disturbances Insomnia
Sympathetic effects	Hypertension Tachycardia Palpitations
Parasympathetic effects	Hypotension  Vasodilation Bradycardia GI smooth muscle contraction  Uterine contraction  Gallbladder contraction Abdominal pain Bronchial smooth muscle contraction: Increased secretions, Dyspnea

6 Drug Interactions

Biobrains should not be used with:

Neostigmine: Increased risk of side effects

MAOIs: Reduced efficacy of both drugs; take Biobrains at least 2 weeks after stopping MAOI

Cholinergic drugs: Increased cardiovascular risk

Anticholinergic drugs: May render Biobrains ineffective

Alcoholic beverages

Dietary advice: Supplement with choline-rich foods such as milk, eggs, and meat.

7 Precautions and Storage

7.1 Precautions

Use with caution in:

• Asthma

• Low blood pressure

• Schizophrenia

• Elderly patients

• Chronic diarrhea

• Poor cerebral circulation

• Heart failure

• Increased muscle stiffness

Take the drug as prescribed. Use only when authorized by a doctor. Discontinue if overdose or hypersensitivity occurs.

7.2 Pregnancy and lactation

Not recommended for pregnant or breastfeeding women with psychiatric disorders or brain injuries.

7.3 Overdose Management

Discontinue if overdose occurs.

Adhere strictly to prescribed dose.

7.4 Storage

Keep out of reach of children. Store at <30°C, protected from sunlight and excessive humidity

8 Manufacturer

Registration Number: VD-35350-21

Manufacturer: Central Pharmaceutical Joint Stock Company 3

Packaging: Box of 3 blisters × 5 vials × 7 ml

9 Price

Biobrains 600 mg/7 ml is sold at Central Pharmacy Online. For detailed price and promotional information, contact the pharmacy at 0388 606 009.

10 Purchase Locations

Available at Central Pharmacy, 85 Vu Trong Phung, Thanh Xuan, Hanoi. Orders can also be placed via hotline or website messaging

11 Advantages

• Oral solution convenient for various users

• Choline is well tolerated, safe, and may be recommended for prevention of dementia in high-risk patients, especially elderly patients with mild cognitive impairment

• Strict quality control under GMP-WHO standards

• Choline alfoscerate has been shown to improve cognitive function after seizures by reducing neuronal death, preserving the blood-brain barrier, and promoting neurogenesis

• Provides neuroprotective effects and improves cognitive decline

12 Disadvantages

• Not suitable during pregnancy

• May cause side effects

Note: This product is sold by prescription only. All information on the website is for reference purposes.

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